Viruses, Free Full-Text
Por um escritor misterioso
Last updated 05 julho 2024
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Tick-borne encephalitis virus (TBEV), a member of the Flaviviridae family, Flavivirus genus, is responsible for neurological symptoms that may cause permanent disability or death. With an incidence on the rise, it is the major arbovirus affecting humans in Central/Northern Europe and North-Eastern Asia. Neuronal death is a critical feature of TBEV infection, yet little is known about the type of death and the molecular mechanisms involved. In this study, we used a recently established pathological model of TBEV infection based on human neuronal/glial cells differentiated from fetal neural progenitors and transcriptomic approaches to tackle this question. We confirmed the occurrence of apoptotic death in these cultures and further showed that genes involved in pyroptotic death were up-regulated, suggesting that this type of death also occurs in TBEV-infected human brain cells. On the contrary, no up-regulation of major autophagic genes was found. Furthermore, we demonstrated an up-regulation of a cluster of genes belonging to the extrinsic apoptotic pathway and revealed the cellular types expressing them. Our results suggest that neuronal death occurs by multiple mechanisms in TBEV-infected human neuronal/glial cells, thus providing a first insight into the molecular pathways that may be involved in neuronal death when the human brain is infected by TBEV.
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Modular approach to customise sample preparation procedures for viral metagenomics: a reproducible protocol for virome analysis
How Nanophotonic Label-Free Biosensors Can Contribute to Rapid and Massive Diagnostics of Respiratory Virus Infections: COVID-19 Case
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16 Best Free Bootable Antivirus Tools (September 2023)
![Viruses, Free Full-Text](https://cgspace.cgiar.org/bitstream/handle/10568/101684/U19ArtSilvaMolecularInthomDev.pdf.jpg?sequence=6&isAllowed=y)
Molecular characterization of a new virus species identified in yam (Dioscorea spp.) by high-throughput sequencing
![Viruses, Free Full-Text](https://www.shutterstock.com/image-illustration/realistic-3d-illustration-covid19-virus-260nw-1703444803.jpg)
66,493 Virus Structure Images, Stock Photos, 3D objects, & Vectors
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Prevalence of respiratory viruses in community-acquired pneumonia in children: a systematic review and meta-analysis - The Lancet Child & Adolescent Health
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How to Tell If You Have a Computer Virus
![Viruses, Free Full-Text](https://pbs.twimg.com/media/GA6ZF-zWkAAAI2b.jpg)
DiedSuddenly on X: Study shows that the Covid 19 Vaccine is RE-ACTIVATING viruses and diseases that were once dormant in people. / X
![Viruses, Free Full-Text](https://www.nejm.org/na101/home/literatum/publisher/mms/journals/content/nejm/2022/nejm_2022.387.issue-19/nejmra2208860/20221107/images/img_medium/nejmra2208860_f1.jpeg)
Monkeypox
![Viruses, Free Full-Text](https://onlinelibrary.wiley.com/cms/asset/77591de3-8163-4704-aa78-e8f246facf12/jvh12619-toc-0001-m.jpg)
Journal of Viral Hepatitis
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Viruses take center stage in cellular evolution, Genome Biology
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Screening and Testing for Hepatitis B Virus Infection: CDC Recommendations — United States, 2023
Coxsackie B viruses and myalgic encephalomyelitis. - Abstract - Europe PMC
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